Big data commonly are characterized by the 3 Vs: volume, variety, and velocity.1 Big data enable the recognition of complex patterns across diverse data types and sources, particularly when combined with artificial intelligence techniques, often leading to novel hypotheses and insights. As a result, the rise of big data has transformed health care research, especially in ophthalmology, where electronic health records (EHRs) and imaging are routinely collected from clinical practice, and big data resources can be leveraged for scientific discovery.
