Children with Down syndrome are naturally predisposed to a variety of ophthalmic disorders, some with a significant impact on vision.The National Down Syndrome Society reports a 60% to 80% prevalence of eye problems in this population, from less severe abnormalities such as nasolacrimal duct obstruction, slanting palpebral fissures and epicanthal folds to vision-threatening diagnoses such as high refractive errors, optic nerve anomalies, keratoconus and cataract.High-sensitivity vision screening programs, a multidisciplinary approach and specialized, consistent eye care from birth are crucial