We appreciate the comments made in the correspondence to the editor regarding our IRIS® Registry (Intelligent Research In Sight) study reporting on the frequency of cataract surgery and associated acute postoperative endophthalmitis among patient eyes with preexisting uveitis, immunosuppressive therapy, and/or systemic corticosteroid treatment. In their correspondence, Kopplin and Armbrust discuss the uncertainty inherent in coded diagnoses, which could represent misdiagnoses or conservative management of cases as endophthalmitis in clinical practice (e.g.